Search results for "CARDIAC STEM CELLS"

showing 10 items of 13 documents

Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardioto…

2015

Although treatment for heart failure induced by cancer therapy has improved in recent years, the prevalence of cardiomyopathy due to antineoplastic therapy remains significant worldwide. In addition to traditional mediators of myocardial damage, such as reactive oxygen species, new pathways and target cells should be considered responsible for the impairment of cardiac function during anticancer treatment. Accordingly, there is a need to develop novel therapeutic strategies to protect the heart from pharmacologic injury, and improve clinical outcomes in cancer patients. The development of novel protective therapies requires testing putative therapeutic strategies in appropriate animal model…

Cardiac function curveACE inhibitorsCardiotonic AgentsNeuregulin-1CardiomyopathyAntineoplastic AgentsPreclinical modelsCardioprotectionCardiotonic AgentsPharmacologyBioinformaticsmedicine.disease_causeCancer therapy-induced cardiac injury ;Preclinical modelsMitochondria HeartBeta-blockersNeoplasmsCancer therapy-induced cardiac injuryMedicineAnimalsHumansCardiac stem cellsCardioprotectionCardiotoxicityACE inhibitors; Beta-blockers; Cancer therapy-induced cardiac injury; Cardiac stem cells; Cardioprotection; Mitochondria; Neuregulin-1; Oxidative stress; Preclinical models; Statinsbusiness.industryStatinsCancermedicine.diseaseCardiotoxicityMitochondriaCancer therapy-induced cardiac injury Preclinical models Cardioprotection Mitochondria Neuregulin-1 Oxidative stress Statins Beta-blockers ACE inhibitors Cardiac stem cellsDisease Models AnimalOxidative StressHeart failureCardiology and Cardiovascular MedicinebusinessOxidative stress
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Synthetic scaffolds may be used for the orientation of cardiac stem cells properties, differentiation and extracellular matrix interactions in cardia…

2011

Cardiac stem cells
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Cardiac Stem Cells their origin and their application

2011

Cardiac stem cells
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Biomaterials and bioactive molecules to drive differentiation in striated muscle tissue engineering

2014

Tissue engineering is an innovative, multidisciplinary approach which combines (bio)materials, cells and growth factors with the aim to obtain neo-organogenesis to repair or replenish damaged tissues and organs. The generation of engineered tissues and organs (e. g. skin and bladder) has entered into the clinical practice in response to the chronic lack of organ donors. In particular, for the skeletal and cardiac muscles the translational potential of tissue engineering approaches has clearly been shown, even though the construction of this tissue lags behind others given the hierarchical, highly organized architecture of striated muscles. Cardiovascular disease is the leading cause of deat…

Cardiac stem cells tissue engineering biomolecules striated muscle
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Fibroin and poly-lactic acid scaffolds may be used in cardiac tissue engineering to drive the differentiation of cardiac progenitor cells: in vitro a…

2011

Cardiac stem cellsCardiac Tissue Engineering
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microRNAs and cardiac progenitor cells

2012

MicroRNAsCardiac stem cells
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CARDIAC STEM CELLS AND BIOMATERIALS: INDUCTION OF MYOGENIC DIFFERENTIATION AND IMPLANTION OF BIOSYNTHETIC AND NATURAL MATRICES IN THE ADULT HEART

2014

Principal purpose of regenerative medicine for the cardiac tissue is to find the best way to inoculate stem cells in a specific myocardial area damage, improving their homing, integration and survival. To achieve this goal, the field of biomaterials is important to bypass this obstacles, modulating the environment for implanted cells and enhance CSC function in the heart. Biomaterials can mimic or include naturally occurring extracellular matrix and instruct stem cell function in different ways: promoting angiogenesis, enhancing stem cell engraftment and differentiation, and accelerating electromechanical integration of transplanted cells. The aim of this thesis was to assess whether the pr…

Settore BIO/16 - Anatomia UmanaSCAFFOLDMYOGENIC DIFFERENTIATIONCARDIAC STEM CELLSBIOMATERIALS
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Cardiac progenitor cells and the development of the human heart

2009

Settore BIO/16 - Anatomia Umanaprecardiac cells cardiac stem cells
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Poly-lactic acid and fibrinoin scaffolds as three-dimensional device to differentiate cardiac stem cells: in vitro and in vivo studies

2010

Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010

cardiac stem cells cardiac surgery scaffolds tissue engineeringCardiac stem cells; cardiac surgery; scaffolds; tissue engineeringSettore M-EDF/01 - Metodi E Didattiche Delle Attivita' Motorie
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The role of biomaterials in the direction of cardiac stem cells properties, differentiation and extracellular matrix interactions in cardiac tissue e…

2011

Introduction: One of the main problems in the rapid translation of preclinical cell‐based therapy to restore damaged myocardium is to find the best delivery route and the best time of cell injection into the myocardium. Intramyocardial injection of stem cells is by far the mostused delivery technique in preclinical studies. Three‐dimensional scaffolds may be used to deliver a limited number of stem cells in their undifferentiated state, but many biomaterials may cause a foreign body reaction on their own. We have recently demonstrated that c‐Kit positive cardiac progenitor cells are able to organize themselves into a tissue‐like cell mass in collagen I three‐dimensional cultures within 72h …

cardiac stem cells scaffolds tissue engineering
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